White matter abnormalities in Parkinson’s disease patients with cognitive impairment


  • There are microstructural changes in the corpus callosum in Parkinson’s disease (PD) patients and they are associated with increased cognitive impairment.  

Why this matters

  • Grey matter atrophy has been observed in PD patients with cognitive impairment, but microstructural white matter abnormalities in the corpus callosum may contribute to cognitive impairment in PD patients.