In patients newly diagnosed with Parkinson’s disease (PD), weight loss is associated with a faster decline in executive function and global cognition, whilst weight gain is linked to slower decline in attention and speed of processing.
Why this matters
PD is a common neurodegenerative disorder that is characterized by motor and non-motor symptoms.
Weight change has been associated with dementia in older individuals; however, any association in patients with PD is unclear.
Understanding the associations of weight changes with cognition in PD might allow clinicians to intervene earlier to support weight management to protect or rehabilitate cognitive function.