Understanding the role of hormone replacement therapy in risk of dementia


  • Hormone replacement therapy (HRT) is associated with an increased risk of dementia, especially Alzheimer’s disease and vascular dementia.

Why this matters?

  • Women have a higher lifetime risk for dementia, which could be associated with hormonal changes after menopause. Estrogen plays a key role in several key neuromodulation activities and has the potential to influence brain physiology implicated in dementia.

  • Hormone replacement therapy has also been linked with increased inflammatory markers and risk of stroke. To date, there has been conflicting evidence surrounding the risk or benefit of HRT and dementia.

  • A comprehensive understanding of the effects of postmenopausal hormone replacement therapy (HRT) on the risk of dementia is critical in providing evidence-based clinical advice for preventing or slowing progression of dementia in individuals at risk.