Understanding the causes of language decline following temporal lobe epilepsy surgery

  • Patients with temporal lobe epilepsy who underwent surgery (n=127) also underwent neuropsychological testing pre- and post-operatively. There were significant differences in post-operative outcomes depending on the location of resection.
  • Surgical damage to the arcuate or inferior fronto-occipital region in language dominant resections and increased middle longitudinal damage in non-language dominant resections, correlated to greater language decline.
  • Substantial language decline following epilepsy surgery involving resection in the language dominant hemisphere is common. The authors concluded that such decline is associated with white matter fiber transection.