Uncovering the role of phosphodiesterase 4 in excessive daytime sleepiness in Parkinson’s Disease


  • First human study to show that phosphodiesterase 4 (PDE4) is involved in the pathophysiology of excessive daytime sleepiness (EDS) observed in Parkinson’s Disease (PD).

Why this matters

  • EDS is one of the most common sleep disturbances in PD but the underlying mechanisms are not fully understood; preclinical studies have suggested a link between PDE4 expression and EDS.