The role of gut microbiota-dependent T cells in progression of multiple sclerosis


  • In people with multiple sclerosis (MS), gut trophic CRR9+ memory T (Tm) cells have a key regulatory role in secondary progressive multiple sclerosis (SPMS) pathogenesis with a reduction in peripheral blood, movement towards an inflammatory phenotype, upregulated expression of the lymphocyte-activating gene 3 (LAG3) in CSF and production of disease-protective cytokines.

  • In mice with experimental autoimmune encephalitis (EAE), a model of MS, antibiotic treatment and inhibition of cell migration in the gut, reduced symptoms of EAE suggesting involvement of gut microbiota in disease progression.

Why this matters

  • Progression from relapsing-remitting MS (RRMS) to SPMS may be attenuated by CCR9+ Tm cells and affected by age or changes in gut microbiota causing CNS inflammation.