The role of arterial blood gas parameters on the progression of disease in amyotrophic lateral sclerosis

  • Arterial blood gas (ABG) parameters including bicarbonates (HCO3-), oxygen partial pressure (pO2), carbon dioxide partial pressure (pCO2), base excess (BE), oxygen saturation, and oxyhemoglobin were evaluated to determine the potential correlation with forced vital capacity (FVC).
  • All ABG parameters investigated were significantly correlated with FVC in patients with spinal or bulbar onset and predicted the survival of amyotrophic lateral sclerosis (ALS).
  • Authors concluded that ABG analysis could be used an alternative to FVC in cases where spirometry cannot be performed.