Summary Summary Short summary of a recent publication, written by scientific experts. Published: 13 Mar 2023

The relationship between trimethylamine N-oxide and the progression of Parkinson’s disease

  • An exploratory Mendelian randomization study to examine the relationship between trimethylamine N-oxide (TMAO) and any precursors, and their causal effects on Parkinson’s disease.
  • Data suggests an inverse causal effect of TMAO on motor fluctuations and carnitine on insomnia.
  • A positive causal effect was observed from betaine on Hoehn-Yahr stage, Unified Parkinson's Disease Rating Scale (UPDRS) III score, and motor fluctuations, and from choline on UPDRS IV and modified Schwab and England Activities of Daily Living Scale score.