The potential benefits of a low glutamate diet as treatment in a pediatric cohort with epilepsy

  • Glutamate is an important neurotransmitter in the body which mediates seizure activity. Current diets prescribed for people with epilepsy lack nutrients that may help with reduced seizure frequency; thus, the potential of a low glutamate diet (LGD) may be a favorable treatment adjunct for a pediatric cohort (2 to 21 years; ≥4 seizures per month) with epilepsy.
  • This study highlights seizure reduction in 21% of participants and non-seizure improvements for 63% of participants. Additionally, an LGD increased nutrient and antioxidant intake; however, 53% of participants had adverse events.
  • According to the authors, an LGD diet can be used as a treatment adjunct before drug-resistant epilepsy manifests in children and adolescents.