The mutation spectrum of early-onset Parkinson’s disease: a Chinese population study


  • PRKN, LRRK2, PINK1, and SNCA are the most frequently mutated genes in Chinese patients with early-onset Parkinson’s disease (EOPD). The role of CHCHD2 in the pathogenicity of PD is confirmed and should be explored further.

Why this matters

  • Genetic studies of large EOPD cohorts in non-Caucasian populations are limited.

  • Establishing the mutation spectrum of EOPD could help to develop effective screening strategies.