Takeaway
PRKN, LRRK2, PINK1, and SNCA are the most frequently mutated genes in Chinese patients with early-onset Parkinson’s disease (EOPD). The role of CHCHD2 in the pathogenicity of PD is confirmed and should be explored further.
Why this matters
Genetic studies of large EOPD cohorts in non-Caucasian populations are limited.
Establishing the mutation spectrum of EOPD could help to develop effective screening strategies.