The link between elevated serum neurofilament light chain levels and prognosis in multiple sclerosis

  • A study involving 199 people with multiple sclerosis (MS) and 49 controls aimed to determine the relationship between serum neurofilament light chain (sNfL) levels and disease progression.
  • Elevated baseline sNfL levels correlated with atrophy measures of the whole brain, white matter, thalamus, and putamen, as measured by magnetic resonance imaging. Among people with MS, those with high sNfL levels at baseline and during follow-up (median 3.8 years) had a significantly increased risk for worsening disability.
  • In light of these findings, the authors conclude that serial measurement of sNfL may be valuable for the clinical management of MS.