The impact of vascular risk factors and Alzheimer’s disease biomarkers on cognitive decline


  • Vascular risk factors and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers were independently associated with cognitive decline and were found to have additive, rather than synergistic, effects on cognitive trajectories.

Why this matters

    Few studies have examined whether vascular risk factors and AD biomarkers act independently or synergistically to promote cognitive decline; understanding their relative contributions will aid in possible AD prevention and management.