The association between androgens and Alzheimer’s disease risk: evidence from a European cohort

  • Increased levels of androgens have been shown to lower the risk of developing Alzheimer’s disease (AD) in men.
  • To verify whether this hypothesis is true, the current study provided evidence on the association between elevated androgens (testosterone: P<0.01; dehydroepiandrosterone sulfate: P<0.01; androsterone sulfate: P<0.06) with a decreased risk of AD in European men. In contrast, no association was noted between sex steroid hormones and AD in women.   
  • According to the authors, the neuroprotective benefit of androgens may play a role in prevention or delay an AD diagnosis.