The association between androgens and Alzheimer’s disease risk: evidence from a European cohort

Increased levels of androgens have been shown to lower the risk of developing Alzheimer’s disease (AD) in men.
To verify whether this hypothesis is true, the current study provided evidence on the association between elevated androgens (testosterone: P<0.01; dehydroepiandrosterone sulfate: P<0.01; androsterone sulfate: P<0.06) with a decreased risk of AD in European men. In contrast, no association was noted between sex steroid hormones and AD in women.
According to the authors, the neuroprotective benefit of androgens may play a role in prevention or delay an AD diagnosis.