The ability to rapidly increase muscle force in lower extremities: a more sensitive marker of neurodegeneration


  • In persons with multiple sclerosis (pwMS), the rate of force development (RFD) in knee extensor is preferably sensitive towards neurodegeneration.

Why this matters

  • The most examined feature of lower extremity neuromuscular function in pwMS is maximal muscle strength, also known as maximal muscle force (Fmax). However the ability to rapidly increase muscle force, measured by RFD, may be just as important.

  • Knee extensor RFD could serve as a simple objective marker of disability status or even progression in pwMS.