SummaryShort summary of a recent publication, written by scientific experts.
Published: 01 May 2023
Tau microtubule binding region predicts pathological changes in dominantly inherited Alzheimer's disease
In Alzheimer’s disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease progression.
This longitudinal, cross-sectional study evaluated the microtubule binding region of tau (MTBR-tau) species of CSF in dominantly inherited AD carriers (n=229) and non-carriers (n=130). CSF MTBR-tau species found on the border and core region of neurofibrillary tangles predicts AD onset. Additionally, CSF MTBR-tau border and core species indicated amyloidosis and neurodegeneration throughout AD evolution.
According to the authors, CSF MTBR-tau species serves as a biomarker of disease onset and neuropathological changes throughout the evolution of AD.