Takeaway
Immunofluorescence and real-time quaking-induced conversion can both accurately differentiate synucleinopathies in skin biopsies.
Why this matters ?
These novel findings demonstrate the applicability of immunofluorescence and real-time quaking-induced conversion techniques in detecting synucleinopathies in vivo. The ability to employ less invasive diagnostic tools using skin biopsies to detect synucleinopathies as an alternative to cerebrospinal fluid would be welcomed in clinical practice.