Synergistic effects of higher iron and amyloid levels on age-related decreases in brain volumes


  • Imaging revealed synergistic age-related brain factors influencing medial temporal lobe volumes: smaller entorhinal cortex volumes were only found in older people with higher Β-amyloid (Aβ) and iron accumulation.

Why this matters

    The authors suggest that iron may be an important contributor to preclinical stages of pathological aging, which has implications for pathophysiology and development of possible future diagnostic markers.