Significant cognitive impairment and brain iron deposition in patients with primary insomnia.


  • Primary insomnia (PI) patients have significant cognitive impairment and increased iron deposition in several key brain regions, notably the hippocampus.

Why this matters

  • Susceptibility weighted imaging (SWI) can assess tissue iron concentration in vivo instead of using the gold standard of autopsy measurement and may lead to identification of biomarkers as well as insights into the pathophysiological mechanisms of disease.