Sex hormone profiles may affect calcitonin gene-related peptide levels in women with migraine

  • A study evaluated calcitonin gene-related peptide (CGRP) levels measured in the plasma and tear fluid from women with episodic migraine who either had a regular menstrual cycle (RMC, n=30), were taking combined oral contraception (COC, n=30), or were postmenopausal (n=30), and in corresponding control groups without migraine.
  • Among women with RMC, CGRP levels were significantly higher in those with versus without migraine in both the plasma (5.95 vs 4.61 pg/ml) and tear fluid (1.20 vs 0.4 ng/ml). These associations were not seen in postmenopausal women or those taking COC, however.
  • Based on these findings, the authors conclude that sex hormone profiles could influence CGRP levels in women with migraine, and that measuring CGRP in tear fluid is feasible.