Diagnosis of incident PD is associated with a range of risk factors, comorbidities and prodromal symptoms. These may indicate that PD pathology have extrastriatal and extracerebral elements.
Why this matters?
A number of potential risk factors have been linked to the subsequent development of PD. Although most of these studies were relatively small-scale and investigated a limited number of exposures.
This study’s findings shed light on the heterogenous nature of PD pathogenesis, and may be utilized to differentiate between distinct phenotypes of PD, enabling early screening and monitoring.