Risk factors, comorbidities and prodromal symptoms associated with Parkinson’s disease: in a real-world population


  • Diagnosis of incident PD is associated with a range of risk factors, comorbidities and prodromal symptoms. These may indicate that PD pathology have extrastriatal and extracerebral elements.

Why this matters?

  • A number of potential risk factors have been linked to the subsequent development of PD. Although most of these studies were relatively small-scale and investigated a limited number of exposures.

  • This study’s findings shed light on the heterogenous nature of PD pathogenesis, and may be utilized to differentiate between distinct phenotypes of PD, enabling early screening and monitoring.