Retrospective analysis of Argyrophilic Grain Disease in individuals younger than 75 years


  • ArgyrophilicGrain Disease (AGD) was present in relatively young patients, expanding the clinicopathological spectrum of primary tauopathies.

Why this matters

    AGD is a limbic-predominant 4R-tauopathy, the prevalence of which increases with age and frequently overlaps with other neurodegenerative diseases. Analysis of clinical data to identify AGD as either a distinct neurologic tauopathy or a byproduct of aging processes may allow identification of further patients who could benefit from tau-based therapeutic strategies.