Regulatory T cells: a new player in neuromyelitis optica?



  • In patients with neuromyelitis optica spectrum disorders (NMOSD), regulatory T cells (Tregs) have a distinctive gene expression signature and the Treg transcription factor FoxP3 is downregulated versus healthy controls.

Why this matters ?

  • Treg dysfunction plays a role in the pathogenesis of many autoimmune disorders, but no data are currently available on the role of Tregs in NMOSD.