Takeaway
Early cerebrospinal fluid (CSF) glucocerebrosidase (GCase) activity may predict the development of dementia in patients with Parkinson’s disease (PD).
Why this matters
A reduction in GCase activity caused by mutations in the glucocerebrosidase gene (GBA) are common risk factors for PD and dementia in PD (PDD).
If early GCase activity can predict the future development of dementia in patients with PD, prophylactic measures can be recommended for patients with newly diagnosed PD.