Persistent headache following aneurysmal subarachnoid hemorrhage


  • Persistent headache often occurs following aneurysmal subarachnoid hemorrhage (aSAH) potentially lasting for years, but improves with time. In some instances, although underpowered in this study, migrainous features were observed with potential therapeutic implications; further studies are required to confirm this.

Why this matters?

  • aSAH is a rare but devastating type of stroke, usually presenting with headache. The headache can be severe, persist for years and have a significantly deleterious impact on quality of life.

  • The underlying pathophysiological mechanisms of the headache are poorly understood and standard pharmacological management such as acetaminophen with or without opioids for post-aSAH headache does not significantly improve symptoms.