Periventricular gradient of neuroinflammation correlates with microstructural damage in MS


  • Patients with multiple sclerosis (MS) showed a periventricular gradient of both innate immune cell activation and associated microstructural damage in the white matter (WM); this gradient was higher in clinically worsening patients.  

Why this matters

  • In MS, irreversible central nervous system injury leads to disability worsening.

  • Prior evidence suggested that proximity to cerebrospinal fluid (CSF), and potentially CSF-derived pro-inflammatory cytokines, predisposes to cortical damage, leading to a periventricular gradient of microstructural damage.

  • Through studying the biological mechanism underlying the relationship between CSF proximity and tissue injury in vivo, disability worsening in MS can be explained and targeted.

    Post-mortem evidence indicated an involvement of activated microglial cells.