Summary Summary Short summary of a recent publication, written by scientific experts. Published: 18 Jan 2021

Novel disease-associated variants in LAMP3 and BST1 with rapid eye movement sleep behavior disorder

Takeaway

  • Rare coding genetic variants in BST1 and rare non-coding variants in LAMP3 are linked to isolated rapid eye movement (REM) sleep behavior disorder.

Why this matters

    This is the largest genetic study of isolated REM sleep behavior disorder to date. The novel findings suggest that loss-of-function of BST1 could be a novel therapeutic target for this disorder.