Young adults with MAPT, C9orf72, and GRN mutations exhibit early changes in brain structure and function, nearly 30 years prior to expected symptom onset.
Why this matters
Symptoms of frontotemporal dementia can proceed clinical diagnosis by decades. Recently, differences in brain structure have been observed in pre-symptomatic, genetic mutation carriers and non-carriers.
These results will shed light on neurodevelopmental changes that may contribute to pathogenesis of frontotemporal dementia, and inform future clinical trial designs.