Summary Summary Short summary of a recent publication, written by scientific experts. Published: 01 May 2019

Multiple sclerosis B cells release factors toxic for oligodendrocytes

Takeaway

  • Multiple sclerosis (MS) B cells release factors toxic for oligodendrocytes (OLs) in extracellular microvesicle fractions with characteristics of exosomes.

Why this matters

    B cells entering the meninges and cerebrospinal fluid (CSF) from the circulation may release factors that cause damage to OLs/myelin and neurons/axons resulting in injury characteristic of MS.