Mood and memory impairments in temporal lobe epilepsy are not contingent on brain lesions


  • MRI-negative temporal lobe epilepsy (TLE) is associated with memory and mood dysfunction equivalent to that observed in people with hippocampal sclerosis or other MRI-resolvable pathologies.

Why this matters

  • To date, studies comparing memory in MRI-negative TLE to lesional cases have not been sufficiently powered, have not included comparator groups, and reported mixed findings.