Markers associated with worse outcomes in epilepsy surgery

  • Epilepsy surgery often fails to achieve seizure freedom, with 30–40% of individuals still experiencing seizures after surgery.
  • Almost all (95%) of patients who were not seizure free following surgery had at least one of three factors: mislocation of resection, only partial resection, or insufficient impact of the overall cortical abnormality.
  • In the absence of any of the above identified markers, 80% of patients were seizure free. The authors concluded that a higher rate of seizure freedom is possible when epilepsy surgery is performed optimally using knowledge of localization of pathology.