Inter-individual topographic variability of the Circle of Willis in children and radiation-related toxicity


  • Based on the low inter-individual topographic variability of the Circle of Willis found in this study, reliable retrospective estimations of radiotherapy doses can be delivered to these arterial structures.

Why this matters

  • Research shows a significant increase in morbidity and mortality due to long-term iatrogenic effects of radiotherapy on arterial structures, especially in children with brain tumors.

  • Although recent studies have found an increased risk of stroke due to the radiation-related toxicity, no recommendations currently exist for the contouring and dose limitations for Circle of Willis irradiation.

  • Establishing a dose-response relationship depends on accurate and reproducible retrospective dosimetric estimations/dose reconstruction in large cohorts of patients who have received radiotherapy in the past.