Individuals from more deprived neighborhoods are more likely to experience cortical thinning and cognitive decline


  • In older cognitively normal adults, neighborhood-level disadvantage is linked to longitudinal cortical thinning and cognitive decline.

Why this matters

  • The association between neighborhood-level disadvantage and faster decline in cortical thickness and cognitive performance suggests that enhanced clinical awareness for early signs of dementia is needed in this vulnerable population.

  • Better understanding of the social and biological pathways linking neighborhood-level disadvantage, neurodegeneration and cognitive decline could ultimately lead to better prevention and intervention in dementia.