Impact of idiopathic rapid eye movement sleep behavior and mood disorders on gray matter volume

Takeaway

• People with idiopathic rapid eye movement sleep behavior disorder (iRBD) and symptoms of depression or anxiety have decreased gray matter (GM) volume in associated brain regions compared to individuals with iRBD without mood symptoms and healthy individuals.

Why this matters

Correlation of GM volume loss and mood symptoms in iRBD provides further insight into underlying pathophysiology in this population at high risk for Parkinson’s disease and other synucleinopathies.