Hypertension, white matter hyperintensities, and cognitive deficits

Analysis of 560 participants of the 1000BRAINS study found that white matter hyperintensities (WMH) was most common in the frontal lobe, followed by parietal, temporal, then occipital lobe.
Higher Fazekas scores, a measure of WMH, were associated with higher blood pressure and antihypertensive treatment. Higher scores correlated to lower executive function and verbal- and non-verbal memory.
The authors concluded that WMH are promoted by vascular risk factors such as hypertension and are associated with cognitive deficits