How is functional connectivity altered by deep brain stimulation in Parkinson’s disease?


  • Targeting the subthalamic nuclei (STN) and internal globus pallidus (GPi) with deep brain stimulation (DBS) resulted in differential patterns of functional connectivity modulation in patients with Parkinson’s disease (PD).

Why this matters

  • Targeting the STN or GPi with DBS can improve motor symptoms and quality of life in PD. The specific effects of targeting either nuclei on brain functional connectivity has not been well studied.

  • Further investigation is required to determine whether differences in functional connectivity induced by STN and GPi DBS in this study translate to varying clinical benefits in patients with PD.