Heterogeneous transitions, reversions, and predictors of mild cognitive impairment


  • The probability of cognitive improvement or decline in individuals with mild cognitive impairment (MCI) is similar. Post-reversion to <MCI, participants remain at increased risk of progression to MCI or dementia and may undergo recurrent reversions.

Why this matters

  • Heterogeneous transitions and the reversion of MCI to normal cognition (NC) is not widely understood.

  • It is important to accurately predict MCI trajectories and determine whether MCI should be considered benign with a high chance of reversal to NC, malignant with a high chance of progression to dementia or both.