The probability of cognitive improvement or decline in individuals with mild cognitive impairment (MCI) is similar. Post-reversion to <MCI, participants remain at increased risk of progression to MCI or dementia and may undergo recurrent reversions.
Why this matters
Heterogeneous transitions and the reversion of MCI to normal cognition (NC) is not widely understood.
It is important to accurately predict MCI trajectories and determine whether MCI should be considered benign with a high chance of reversal to NC, malignant with a high chance of progression to dementia or both.