Grid cell activity within entorhinal cortex linked to schizophrenia


  • Disrupted hexadirectional theta power modulation and reduced theta oscillations within the entorhinal cortex are linked to the pathogenesis of schizophrenia.

Why this matters

  • During spatial navigation, specialized grid cells within the entorhinal and medial prefrontal cortex exhibit hexadirectional modulation of neural activity. It is likely that this pattern might be disrupted in schizophrenia.

  • A more comprehensive understanding of the pathophysiology of schizophrenia will potentially define new therapeutic targets for intervention.