Disrupted hexadirectional theta power modulation and reduced theta oscillations within the entorhinal cortex are linked to the pathogenesis of schizophrenia.
Why this matters
During spatial navigation, specialized grid cells within the entorhinal and medial prefrontal cortex exhibit hexadirectional modulation of neural activity. It is likely that this pattern might be disrupted in schizophrenia.
A more comprehensive understanding of the pathophysiology of schizophrenia will potentially define new therapeutic targets for intervention.