Summary Summary Short summary of a recent publication, written by scientific experts. Published: 28 Jan 2019

Genetic variation in PLEKHG1 associated with increased white matter hyperintensities and stroke risk

Takeaway

  • PLEKHG1 genetic variation is associated with increased white matter hyperintensities (WMH), lacunar stroke, and deep intracerebral hemorrhages, potentially through disruption of small vessel endothelia.

Why this matters ?

  • Identifying underlying genetic causes for the development of WMH may help in the development of treatments for cerebral small vessel disease.