Summary Summary Short summary of a recent publication, written by scientific experts. Published: 13 Mar 2023

Fluctuation of neuronal excitability and modulation of interictal epileptic events

Patients with drug-resistant focal epilepsy were assessed via simultaneous polysomnography during intracranial electroencephalographic recording.
Phases of scalp sleep slow waves (SSWs) were mapped, and the relative positions of intracranial spikes and ripples within the phases were identified.
Phase analysis revealed intracranial spikes and ripples accumulated around the negative peaks of SSWs in an amplitude-dependent pattern and were facilitated predominantly during cortical down state.