Fluctuation of neuronal excitability and modulation of interictal epileptic events

  • Patients with drug-resistant focal epilepsy were assessed via simultaneous polysomnography during intracranial electroencephalographic recording.
  • Phases of scalp sleep slow waves (SSWs) were mapped, and the relative positions of intracranial spikes and ripples within the phases were identified.  
  • Phase analysis revealed intracranial spikes and ripples accumulated around the negative peaks of SSWs in an amplitude-dependent pattern and were facilitated predominantly during cortical down state.