Electroencephalography as a marker for disease severity in amyotrophic lateral sclerosis

  • Assessed via eyes closed electroencephalography (EEG) and compared with healthy controls, spectral beta-band power in motor and frontal regions was found to be associated with disease burden for individuals with amyotrophic lateral sclerosis (ALS). Higher beta-band power correlated with higher disease burden.
  • Microstate duration was also associated with disease severity with longer duration associated with poorer clinical status.  
  • The authors concluded that EEG can be used as a marker of disease severity in ALS.