Electroencephalography as a marker for disease severity in amyotrophic lateral sclerosis

Assessed via eyes closed electroencephalography (EEG) and compared with healthy controls, spectral beta-band power in motor and frontal regions was found to be associated with disease burden for individuals with amyotrophic lateral sclerosis (ALS). Higher beta-band power correlated with higher disease burden.
Microstate duration was also associated with disease severity with longer duration associated with poorer clinical status.
The authors concluded that EEG can be used as a marker of disease severity in ALS.