Efficacy of deep brain stimulation for X-linked dystonia parkinsonism


  • In a small study of individuals with X-linked dystonia parkinsonism, deep brain stimulation (DBS) of the internal globus pallidus (GPi) was effective in improving motor symptoms quickly and the effect was sustained long-term.

Why this matters

  • Oral drug treatments for X-linked dystonia parkinsonism are largely ineffective, so DBS should be considered as a first line therapy for medially intractable X-linked dystonia parkinsonism.