Takeaway
Cognitive reserve and brain reserve differentially influence the cognitive trajectory of Alzheimer’s disease, but both factors protect against mortality.
Why this matters
Little is currently known about the relationship between education and intracranial volume and the trajectory of dementia; this unique study assessed the impact of cognitive and brain reserve in an amyloid-β-positive memory clinic sample.
The findings could facilitate prognostic accuracy in clinical practice based on an individual’s education level and magnetic resonance imaging-assessed intracranial volume.