Education and intracranial volume differentially affect cognitive trajectories and mortality in Alzheimer’s disease


  • Cognitive reserve and brain reserve differentially influence the cognitive trajectory of Alzheimer’s disease, but both factors protect against mortality.

Why this matters

  • Little is currently known about the relationship between education and intracranial volume and the trajectory of dementia; this unique study assessed the impact of cognitive and brain reserve in an amyloid-β-positive memory clinic sample.

  • The findings could facilitate prognostic accuracy in clinical practice based on an individual’s education level and magnetic resonance imaging-assessed intracranial volume.