Does biological age predict motoric cognitive risk syndrome in an elderly cohort?

  • Motoric cognitive risk syndrome (MCR) is associated with several age-related risk factors, such as age, gender, level of education, physical inactivity, and chronic illnesses. Further investigation on the association between biological age acceleration on MCR and mortality is lacking.
  • MCR was prevalent in the LonGenity (adjusted odds ratio: 1.36) and Health and Retirement study (HRS), and incident MCR (hazard ratio [HR]: 1.19) was reported in the LonGenity cohort. Prevalent MCR and accelerated aging was associated with increased risk of mortality in both cohorts (LonGenity: HR 3.38; HRS: HR 2.47).
  • According to the authors, biological age acceleration is a useful predictor of MCR risk and is related to higher mortality rates in people with MCR.