Do genetically predicted sleep traits portend post-stroke outcomes?

  • Data from Mendelian randomization studies suggest genetic predisposition to insomnia is associated with significantly worse functional outcomes following ischemic stroke (P=0.002), even when adjusted for confounding traits such as body mass index, depression, type 2 diabetes, smoking, and alcohol consumption. 
  • Genetic predisposition to short sleep, long sleep, and continuous sleep duration were not found to be associated (P>0.05).
  • The authors concluded that Mendelian randomization confirms the negative effect of insomnia on functional outcomes following stroke noted in observational studies.