Defining the clinical phenotype of patients with anti-U1-ribonucleoprotein-positive myositis


  • Pulmonary hypertension (PH), pericarditis and glomerulonephritis occur in patients with anti-U1-ribonucleoprotein (RNP) autoantibodies with coexisting anti-Ro52 autoantibodies but are rare in other myositis groups.

Why this matters

  • Testing for anti-Ro52 in patients with anti-U1-RNP-positive myositis might help identify those who are at risk of developing serious extramuscular manifestations.