Cognitive impairment in the conversion of radiologically isolated syndrome to multiple sclerosis


  • Cognitive impairment (CI), which presents with a similar neuropsychological profile to multiple sclerosis (MS), can be used in the prediction of progression of radiologically isolated syndrome (RIS) to MS.

Why this matters

  • RIS is defined as the observation of white matter lesions in magnetic resonance imaging (MRI) of the brain, in asymptomatic patients, without a history of neurological deficiency, thereby suggesting MS).

  • RIS presents a 5-year risk prognosis rate of 34% conversion to MS.

  • However, 20-30% patients with RIS who are asymptomatic according to neurological examinations, demonstrated CI, which has a profile similar to MS.

  • The correlation between CI and quantitative MRI measures remains unknown.