Chronic brain inflammation and cognitive aging in older adults


  • Chronic brain inflammation, as measured by DNA methylation (DNAm) C-reactive protein (CRP) scores, was associated with neurodegenerative brain changes in older adults.

Why this matters ?

  • Systemic, chronic inflammation has previously been identified as a potential driver of accelerated brain aging, but no standard biomarkers to measure chronic inflammation exist and biomarkers of acute inflammation are often relied upon.

  • As an alternative to the standard measures of peripheral inflammation, the study quantified a genome wide epigenetic modification of DNA (DNA methylation) signature that correlated with serum CRP levels (DNAm CRP).

  • DNAm CRP scores had significantly stronger associations with brain health outcomes than serum CRP, highlighting its potential as a reliable measure of chronic inflammatory status.