Cerebral cavernous malformations: assessing functional outcome and rebleeding risk after multiple hemorrhage

  • Symptomatic hemorrhage contributes to an increased risk of repeated bleeding and morbidity in cerebral cavernous malformation (CCM).
  • The assessment of functional outcome in children (n=55) after initial and multiple intracerebral hemorrhage (ICH) with CCM suggests that brainstem CCM (BSCM, P=0.019) predicts unfavorable outcomes after the second ICH. Outcomes significantly deteriorated in fewer patients after each ICM event. In addition, there was a 10.7% risk of rebleeding during the 1st year after a second occurrence of ICH.
  • According to the authors, children with BSCM experience worse outcomes after a second ICH, with rebleeding greatly contributing to neurological deterioration in this cohort.