Centromedian nucleus-deep brain stimulation is an effective therapy in younger adults with Lennox-Gastaut syndrome


  • Deep brain stimulation to the centromedian thalamic nucleus can reduce seizures in younger adults with Lennox-Gastaut syndrome.

Why this matters

  • Deep brain stimulation is an emerging treatment for Lennox-Gastaut syndrome with increasing off-label use, but evidence from randomized controlled studies is scant. This is the first randomized, double-blind, controlled study to evaluate the efficacy and safety of centromedian nucleus-deep brain stimulation in a carefully selected cohort of young adults.

  • The findings suggest that centromedian nucleus-deep brain stimulation can reduce seizures in this population; this could inform clinicians on how to counsel centromedian nucleus-deep brain stimulation candidates for likely benefit and possible complications.