CCR5-Δ32 mutation may predict better motor recovery in stroke survivors


  • Loss-of-function mutation in the C-C Chemokine receptor 5 gene (CCR5-Δ32) is associated with better gait measures in mild to moderate ischemic stroke survivors.

Why this matters

  • Non-functional or partial loss-of-function of CCR5 protein has been shown to promote certain aspects of stroke recovery. How CCR5-Δ32 may affect motor recovery in stroke survivors is yet to be assessed.

  • Isolating this allele can provide a therapeutic target for improved stroke recovery and help to identify patients who are prone to worse motor outcomes.